Table 2.

Anticancer effects of CDDO and CDDO-Me in vivo described in the text.

Compound	Animal Model	Treatment	Effect(s)	Reference(s)
CDDO-Me	Female A/Jm mice	Oral assumption; 40 mg/kg from the 8th week of age	CDDO-Me reduced number size and severity of lung carcinomas induced by vinyl carbamate; acts synergistically with the rexinoid LG100268	[94]
CDDO -Me	FVB/N-Tg(MMTVneu)202Mul/J female mice	Oral assumption; 60 mg/kg from the 10th week of age for up to 45 weeks	CDDO-Me delays development of ER-negative tumors of 14 weeks; acts synergistically with the rexinoid LG100268	[95]
CDDO-Me	FVB/N-Tg(MMTV-PyVT)634Mul/J mice	Oral assumption; 50 mg/kg	CDDO-Me delays mammary carcinogenesis in PyMT breast ER-negative cancer by 4.3 weeks	[97]
CDDO-Me	Brca1Co/Co; MMTV-Cre;p53+/− mice	Oral assumption; 50 mg/kg	CDDO-Me delays breast cancer development by an average of 5.2 weeks	[96]
CDDO-Me	C57BL/6-Tg(TRAMP)8247Ng/J mice	Oral assumption; 7.5 mg/kg from the 5th week of age; treatment for 7 or 20 weeks.	CDDO-Me inhibits the progression of the preneoplastic lesions to prostate adenocarcinoma; inhibits metastasis	[98,99]
CDDO-Me	LSL-KrasG12D/+; LSL-Trp53R127H/+; Pdx-1-Cre (KPC) mice	Oral assumption; 60 mg/kg from the 4th week of age	CDDO-Me increases mice survival by 3–4 weeks; acts synergistically with rexinoid LG268	[100]
CDDO-Me	Female C57BL/6 mice	Intravenous injections of CDDO-Me nanoparticles; intraperitoneal injections of CDDO-Me every other day (5 mg/kg)	CDDO-Me enhances efficacy of vaccine therapy for melanoma	[101]