Table 2.
Anti-inflammatory terpenoids from marine fungi.
| Metabolites | Species | Activities | Reference |
|---|---|---|---|
| Brasilanones A and E (21, 22) | A. terreus CFCC 81836 | against NO with 47.7% and 37.3% inhibition rates at 40 μM in LPS-activated RAW264.7 cells | [31] |
| Dihydrobipolaroxins B−D (23−25) Dihydrobipolaroxin (26) |
Aspergillus sp. SCSIOW2 | against NO with moderate anti-inflammatory effects | [32] |
| Thomimarine E (27) | P. thomii KMM 4667 | against NO with 22.5% inhibition rate at 10.0 μM in LPS-activated RAW264.7 cells | [33] |
| Graphostromane F (28) | Graphostroma sp. MCCC 3A00421 | against NO with IC50 value of 14.2 μM in LPS-activated RAW264.7 cells | [34] |
| Khusinol B (29) | Graphostroma sp. MCCC 3A00421 | against NO with IC50 values of 17 μM in LPS-activated RAW264.7 cells | [35] |
| 1R,6R,7R,10S-10-hydroxy-4(5)-cadinen-3-one (30) | Hypocreales sp. HLS-104 | against NO with Emax values of 10.22% at 1 μM in LPS-activated RAW264.7 cells | [36] |
| Mangicols A and B (31, 32) | F. heterosporum CNC-477 | 81% and 57% inhibition rate at 50 μg per ear in PMA-induced mouse ear edema assay | [37] |
| Chondroterpenes A, B, H (33–35) Hirsutanol A (36) Chondrosterins A, B (37, 38) |
Chondrostereum sp. NTOU4196 | against NO with considerable inhibitory effects at 20 μM in LPS-activated BV-2 cells | [38] |
| Lovastatin (39) | A. terreus | against NO with IC50 value of 17.45 μM in LPS-activated RAW264.7 cells | [25] |
| Aspertetranones A−D (40−43) | Aspergillus sp. ZL0-1b14 | against IL-6 with 43% and 69% inhibition rates at 40 μM in LPS-activated RAW264.7 cells | [39] |
| Pleosporallins A−C (44−46) | Phoma sp. NTOU4195 | against IL-6 with about 30.0% inhibition rate at 5–20 μg/mL in LPS-activated RAW264.7 cells | [40] |
| 7-acetoxydehydroaustinol (47) Austinolide (48) 7-acetoxydehydroaustin (49) 11-hydroxyisoaustinone (50) 11-acetoxyisoaustinone (51) |
Penicillium sp. SF-5497 | against NO with IC50 values of 61.0, 30.1, 58.3, 37.6, and 40.2 μM in LPS-activated BV-2 cells | [41] |
| Citreohybridonol (52) | P. atrovenetum | anti-neuroinflammatory activity | [42] |
| Tanzawaic acid Q (53) Tanzawaic acids A (54), C (55), D (56), and K (57) |
P. steckii 108YD142 | against NO with considerably anti-inflammatory activity in LPS-activated RAW264.7 cells | [43] |
| 2E,4Z-tanzawaic acid D (58) Tanzawaicacids A (54), E (59) | Penicillium sp. SF-6013 | against NO with IC50 values of 37.8, 7.1, and 42.5 μM in LPS-activated RAW264.7 cells | [44] |
| Stachybotrysin C (60), Stachybonoid F (61), Stachybotylactone (62) | S. chartarum 952 | against NO with IC50 values of 27.2, 52.5, and 17.9 μM in LPS-activated RAW264.7 cells | [45] |