Table 7.
Screening of cytotoxicity of glycoconjugates derivatives of 8-hydroxyquinoline 45–108.
| Compound | Activity IC50 [µM] a | Compound | Activity IC50 [µM] a | ||||
|---|---|---|---|---|---|---|---|
| HCT 116 b | MCF-7 c | NHDF-Neo b | HCT 116 b | MCF-7 c | NHDF-Neo b | ||
| 45 | 217.0 ± 4.7 | 196.5 ± 1.9 | 405.9 ± 5.7 | 49 | >800 | >800 | - |
| 46 | 248.8 ± 7.1 | 196.5 ± 3.1 | 262.4 ± 1.7 | 50 | >800 | >800 | - |
| 47 | 229.6 ± 2.6 | 375.6 ± 8.3 | - | 51 | >800 | >800 | - |
| 48 | 257.1 ± 7.2 | 231.8 ± 9.6 | - | 52 | >800 | >800 | - |
| 53 | 143.0 ± 2.3 | 200.6 ± 1.1 | 214.8 ± 6.4 | 57 | >800 | >800 | - |
| 54 | 168.9 ± 1.0 | 190.4 ± 3.0 | 213.1 ± 3.0 | 58 | >800 | >800 | - |
| 55 | 135.1 ± 7.0 | 221.1 ± 2.4 | 426.8 ± 3.8 | 59 | >800 | >800 | - |
| 56 | 244.8 ± 4.7 | 240.2 ± 3.8 | - | 60 | >800 | 605.2 ± 1.3 | - |
| 61 | 328.8 ± 9.0 | 254.8 ± 3.6 | - | 65 | 382.4 ± 2.1 | 320.2 ± 4.9 | - |
| 62 | 389.5 ± 4.9 | 233.1 ± 5.8 | - | 66 | >800 | 788.8 ± 7.5 | - |
| 63 | 294.7 ± 1.8 | 214.8 ± 1.7 | >800 | 67 | >800 | >800 | - |
| 64 | 499.8 ± 2.7 | 241.9 ± 2.8 | - | 68 | >800 | >800 | - |
| 69 | 240.0 ± 2.3 | 105.9 ± 4.1 | 216.1 ± 9.7 | 73 | >800 | >800 | - |
| 70 | 280.9 ± 8.9 | 217.9 ± 5.2 | 220.0 ± 2.5 | 74 | 426.1 ± 1.3 | >800 | - |
| 71 | 290.6 ± 7.0 | 136.0 ± 1.5 | 715.2 ± 9.6 | 75 | >800 | >800 | - |
| 72 | 763.3 ± 5.4 | 317.8 ± 8.5 | - | 76 | >800 | >800 | - |
| 77 | 246.2 ± 6.2 | 192.7 ± 3.7 | 219.1 ± 2.4 | 81 | 112.8 ± 1.6 | 87.9 ± 4.1 | 94.7 ± 0.5 |
| 78 | 119.1 ± 5.6 | 39.1 ± 0.9 | 103.6 ± 2.5 | 82 | 194.4 ± 0.6 | 384.7 ± 8.3 | 166.3 ± 5.8 |
| 79 | 142.9 ± 2.9 | 226.6 ± 4.0 | 480.8 ± 4.4 | 83 | >800 | >800 | - |
| 80 | 519.2 ± 7.2 | 301.0 ± 4.4 | - | 84 | >800 | >800 | - |
| 85 | 239.1 ± 3.0 | 203.8 ± 3.6 | 382.6 ± 2.4 | 89 | >800 | >800 | - |
| 86 | 270.6 ± 7.5 | 129.7 ± 1.8 | >800 | 90 | 690.3 ± 4.0 | 629.0 ± 1.2 | - |
| 87 | 379.8 ± 1.4 | 211.9 ± 1.1 | >800 | 91 | >800 | >800 | - |
| 88 | 272.3 ± 1.2 | 178.9 ± 6.8 | >800 | 92 | >800 | >800 | - |
| 93 | 137.3 ± 2.1 | 95.7 ± 0.02 | 113.4 ± 0.9 | 97 | 677.9 ± 2.8 | 702.6 ± 1.9 | - |
| 94 | 229.8 ± 4.7 | 256.0 ± 9.6 | - | 98 | >800 | >800 | - |
| 95 | 217.1 ± 1.5 | 781.2 ± 3.5 | 163.1 ± 1.1 | 99 | >800 | 595.9 ± 9.0 | - |
| 96 | 249.2 ± 5.5 | 297.9 ± 2.1 | - | 100 | >800 | >800 | - |
| 101 | 246.2 ± 1.3 | 176.4 ± 1.8 | 696,7 ± 1.6 | 105 | >800 | 436.3 ± 3.1 | - |
| 102 | 369.0 ± 4.7 | 203.6 ± 4.9 | - | 106 | >800 | >800 | - |
| 103 | 295.2 ± 8.2 | 177.6 ± 2.6 | 586.0 ± 5.6 | 107 | 630.2 ± 2.7 | >800 | - |
| 104 | 515.7 ± 4.3 | 223.4 ± 8.6 | - | 108 | >800 | >800 | - |
a Cytotoxic was evaluated using the MTT assay; b Incubation time 24 h; c Incubation time 72 h.