Effects of COS on mRNA expression related to hepatic antioxidant capacity in mice: relative mRNA expressions of NQO1 (A), HO-1 (B), and GSTA1 (C) in livers. Data are presented as the mean ± SE (n = 5−6 per group). Results were statistically analyzed using one-way ANOVA followed by Duncan’s multiple-comparison test, and values with different labels (a–c) are significantly different (p < 0.05). NCD, normal chow diet group; HFD, high-fat diet group; HFDLC, high-fat diet + low dosage of COS (200 mg/kg BW) group; HFDHC, high-fat diet + high dosage of COS (400 mg/kg BW) group. NQO1, NADPH quinone oxidoreductase 1; HO-1, heme oxygenase-1; GSTA1, glutathione S-transferase alpha 1.