Table 1.
Effects of chitosan oligosaccharide (COS) on serum biochemical parameters in mice.
| NCD | HFD | HFDLC | HFDHC | |
|---|---|---|---|---|
| TC (mmol/L) | 3.03 ± 0.068 c | 5.88 ± 0.295 a | 5.54 ± 0.307 a | 4.82 ± 0.151 b |
| TG (mmol/L) | 0.44 ± 0.020 | 0.48 ± 0.026 | 0.45 ± 0.018 | 0.44 ± 0.025 |
| HDL (mmol/L) | 3.48 ± 0.234 b | 6.01 ± 0.250 a | 6.48 ± 0.188 a | 6.43 ± 0.294 a |
| LDL (mmol/L) | 0.53 ± 0.032 c | 1.28 ± 0.142 a | 1.01 ± 0.112 a,b | 0.98 ± 0.044 b |
| LDL/HDL | 0.154 ± 0.010 b | 0.216 ± 0.027 a | 0.155 ± 0.015 b | 0.154 ± 0.007 b |
| AST (U/L) | 14.06 ± 1.234 b | 21.36 ± 2.668 a | 17.61 ± 1.095 a,b | 14.89 ± 0.810 b |
| ALT (U/L) | 7.55 ± 0.688 b | 9.98 ± 0.438 a | 8.41 ± 0.559 a,b | 7.81 ± 0.555 b |
Data are presented as the mean ± SE (n = 8 per group). Results were statistically analyzed using one-way ANOVA followed by Duncan’s multiple-comparison test, and values with different labels (a–c) within each row are significantly different (p < 0.05). NCD, normal chow diet group; HFD, high-fat diet group; HFDLC, high-fat diet + low dosage of COS (200 mg/kg BW) group; HFDHC, high-fat diet + high dosage of COS (400 mg/kg BW) group. TC, total cholesterol; TG, triacylglycerol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase.