Table A2.

Excitatory effects of spider knottins on Na_V channel subtypes. Values presented were obtained from electrophysiological experiments, unless otherwise as stated.

Toxin	NaSpTx Family	NaV1.1	NaV1.2	NaV1.3	NaV1.4	NaV1.5	NaV1.6	NaV1.7	NaV1.8	NaV1.9	Others
JzTx-I	7		870 nM (n, HT, r) [100]	845 nM (n, HT, r) [100]	339 nM (n, HT, r) [100]	335 nM (n, HT, h) [100]		348 nM (n, HT, h) [100]			130 nM (n, TTX-S currents, rat DRG); No inhibition in rat DRG TTX-R currents; 31 nM in rat cardiac myocytes) [101]
JzTx-II	7			1650 nM (n, HT, r) [98]		125 nM (n, HT, h) [98]
Hm1a	2	38 nM (s, X, h) [20]	236 nM (s, X, h) [20]	220 nM (s, X, h) [20]	No inhibition up to 1000 nM (s, X, h) [20]	No inhibition up to 1000 nM (s, X, h) [20]	No inhibition up to 1000 nM (s, X, h) [20]	No inhibition up to 1000 nM (s, X, h) [20]	No inhibition up to 1000 nM (s, X, h) [20]
PnTx2-1	6	122 nM (n, X, r) [147]	No inhibition up to 1000 nM (n, X, r) [147]	No inhibition up to 1000 nM (n, X, r) [147]	No inhibition up to 1000 nM (n, X, r) [147]	87 nM (n, X, h) [147]	No inhibition up to 1000 nM (n, X, m) [147]		101.1 nM (n, X, r) [147]

Note: s:- synthetic; n:- native; H_T:- transiently transfected HEK 293 cells; X:- Xenopus oocytes; h:- human Na_V; r:- rat Na_V; r:- rat Na_V.