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. 2019 Nov 14;24(22):4119. doi: 10.3390/molecules24224119

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of CS-N on renal functional parameters in STZ-induced diabetic mice. (A) Kidney index, (B) 24-hour urine volume, (C) Alb, (D) SCR, (E) BUN, and (F) TC. Alb: 24-hour urinary albuminuria; SCR: serum creatinine; BUN: blood urea nitrogen; TC: total cholesterol; NC: normal control; DN: diabetic nephropathy model induced by streptozotocin (STZ); ENA: positive control, 1.5 mg/kg/day enalaprilat administration; CS-N40, CS-N80: 40, 80 mg/kg/day CS-N administration. Data are presented as the means ± SDs, n = 6. NS-1 p > 0.05; *** p < 0.001 compared with the NC group; NS-2 p > 0.05; # p < 0.05; ## p < 0.01; ### p < 0.001 compared with the DN group.