Scheme 4.
Chemoenzymatic pathway leading to the S-NAD+ 39 [63]. The enzymatic transformations are marked in blue. Conditions: a) HBr, toluene, 0 °C, 4 h; b) nicotinamide, MeCN, rt, 18 h; c) TFA/H2O, 0 °C, 6 h; d) NH3/MeOH, 0 °C, 48 h.
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