Table 1.
Absorption, distribution, metabolism, excretion, and toxicity (ADMET) and TOPKAT prediction of steviophethanoside.
| Predicted Item | Compound 1 |
|---|---|
| Absorption level (2–4) | 3 |
| BBB level (2–4) | 4 |
| Solubility level | 4 |
| CYP2D6 prediction (False-non inhibitor) | FALSE |
| Hepatotoxic prediction (False-non toxic) | FALSE |
| PPB Prediction (False-poorly bound) | FALSE |
| Mutagen | Non-Mutagen |
| Rodent Carcinogenicity | Non-Carcinogen |
| Skin irritancy | Non-Irritant |
| Skin sensitization | 0.765 |
| Rat oral LD50 (g/kg) | 5.61 |
| Ocular Irritancy | 0.84 |
| DTP (Developmental Toxicity Potential) | 0.861 |