Table 1.
Effect of phlorotannins on Aβ25-35 self-aggregation, bovine insulin glycation, and lipid peroxidation in rat brain homogenates.
| Compounds | IC50 (μM) a | EC50 (μM) a | ||
|---|---|---|---|---|
| Aβ25-35 Aggregation | d-Ribose-Induced Insulin Glycation | d-Glucose-Induced Insulin Glycation | Lipid Peroxidation | |
| Phloroglucinol | >100 | >100 | >100 | >75 |
| Eckol | 34.36 ± 1.11 | 258.54 ± 10.81 | >100 | 38.64 ± 1.16 |
| Dioxinodehydroeckol | 8.31 ± 0.23 | >100 | >100 | 12.43 ± 1.50 |
| Dieckol | 7.93 ± 0.16 | 63.67 ± 3.83 | >100 | 15.48 ± 2.14 |
| Phlorofucofuroeckol-A | 6.18 ± 0.18 | 29.50 ± 0.53 | 43.55 ± 2.38 | 10.96 ± 0.16 |
| Curcumin b | 10.73 ± 1.40 | ‒ | ‒ | ‒ |
| Vanillin c | ‒ | >500 | ‒ | ‒ |
| Rutin b | ‒ | 5.19 ± 1.35 | ||
| Trolox b | ‒ | ‒ | ‒ | 49.01 ± 3.50 |
a The 50% inhibition concentration (IC50) and 50% effective concentrations (EC50) are expressed as mean ± SD, n = 3. b Curcumin, rutin, and Trolox were used as a positive control for the Aβ25-35 aggregation, d-glucose-induced insulin glycation and lipid peroxidation assays, respectively. c Negative control for the d-ribose-induced insulin glycation assay.