Table 2.

Toxicity tests requested by the US Food and Drug Administration for safety evaluations of food additives.

Toxicity Tests	CL Low (I)	CL Intermediate (II)	CL High (III)
Genetic toxicity tests	x	x	x
Short-term toxicity tests with rodents	x	x	x
Subchronic toxicity studies with rodents		x	x
Subchronic toxicity studies with non-rodents		x	x
One-year toxicity studies with non-rodents			x
Chronic toxicity or Combined chronic toxicity/carcinogenicity studies with rodents			x
Carcinogenicity studies with rodents			x
Reproduction studies		x	x
Developmental toxicity studies		x	x
Metabolism and Pharmacokinetic studies		x	x
Human studies			x