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Active site comparison of (A) PDE_Ca with (B) human Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), (C) Ectonucleotide pyrophosphatase-phosphodiesterase-1 (NPP1) (Mus musculus), (D) ENPP2 (human Autotaxin), (E) Xac Nucleotide Pyrophosphatase/Phosphodiesterase (Xanthomonas axonopodis), and (F) Phosphodiesterase Naja atra. Metal ion-binding amino acid residues are displayed as sticks and metal ions as grey spheres.
