Table 2.

Solubility data for selected [b]-annulated indoles.

Compound	Sexp., therm., pH 7.4 [µM] a	Sexp., kin., pH 7.4 [µM] b
KuFal194 (10)	<5	5.28 (4.99–5.57)
11	<5	26.1 (25.6–26.5)
16	13,650 (11,100–16,200)	2310 *

^a Thermodynamic solubility (phosphate buffer pH 7.4) using the shake-flask method. In two independent experiments vials were incubated at 25 °C and quantified by HPLC. Signals lower than the limit of quantification are indicated as <5 µM (lowest concentration used for calibration). Mean value and range are given. ^b Kinetic solubility using nephelometry. Mean value and range are given. * Singlicate measurement.