Table 1.
Bacteriostatic effect of fucoxanthin and isoniazid on Mycobacterium tuberculosis strains and cytotoxicity evaluation.
| Mycobacterial Strains | MIC (µM) | Cytotoxicity (IC50; µM) for Fucoxanthin and INH | SI | ||
|---|---|---|---|---|---|
| Fucoxanthin | INH | Fucoxanthin | INH | ||
| Mtb a | 4.1 | 6.2 | >25 | >6.1 | >4.0 |
| Mtb-A b | 3.9 | 5.8 | >25 | >6.4 | >4.3 |
| Mtb-B b | 3.9 | 5.2 | >25 | >6.4 | >4.8 |
| Mtb-C b | 3.8 | 5.3 | >25 | >6.6 | >4.7 |
| Mtb-D b | 3.5 | 5.5 | >25 | >7.1 | >4.5 |
| Mtb-E b | 3.6 | 5.5 | >25 | >6.9 | >4.5 |
| Mtb-F b | 2.9 | 4.8 | >25 | >8.6 | >5.2 |
| Mtb-G b | 2.9 | 4.9 | >25 | >8.6 | >5.1 |
| Mtb-H b | 3.0 | 5.1 | >25 | >8.3 | >4.9 |
| Mtb-I b | 2.8 | 4.8 | >25 | >8.9 | >5.2 |
| Mtb-J b | 3.1 | 5.2 | >25 | >8.1 | >4.8 |
The displayed values demonstrate the average of three independent measurements conducted in triplicate. a Mtb: Mycobacterium tuberculosis (standard strain; H37Rv CNCTC My 331-88/ATCC 27294); b Mtb: Clinical isolates of Mycobacterium tuberculosis; MIC: minimum inhibitory concentration; INH: isoniazid; IC50: half maximal inhibitory concentration (expressed as toxicological value); SI: selectivity index expressed as the ratio IC50/MIC. The statistical analyses were aided by PRISM software (GraphPad Software, Inc., La Jolla, CA, USA; version 8.0).