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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2019 Oct 10;145:374–384. doi: 10.1016/j.freeradbiomed.2019.10.006

Figure 5. Effects of ischemia-reperfusion on the heart.

Figure 5.

Isolated hearts were subjected to ischemia-reperfusion as described in Methods. (A) Recovery from reperfusion measured as the left ventricular rate-pressure product (RPP). (B) Infarcted area of the left ventricle. The groups are wild type without preconditioning (− PC), 6 female and 6 male; quadruple knockout without preconditioning, 4 male and 4 female; wild type with preconditioning (+PC), 2 male and 2 female; quadruple knockout with preconditioning, 2 male and 2 female. Without preconditioning, the quadruple knockout had a significantly higher RPP (p<0.0001) and lower infarct area (p<0.0001) than the wild type. With preconditioning, there was no significant difference in RPP (p=0.50) nor infarct area (p=0.88). Comparisons were made with the unpaired t-test. The line and bars show the mean and SD.