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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2019 Oct 10;145:374–384. doi: 10.1016/j.freeradbiomed.2019.10.006

Table 2.

Hemodynamic parameters from Langendorff model of ischemia-reperfusion

Pre-ischemic hemodynamic value Post-ischemic hemodynamic value
HR FR LVDP +dp/dt −dp/dt HR FR LVDP +dp/dt −dp/dt
Group n (bpm) (ml/min) (cmH2O) (cmH2O/ms) (bpm) (ml/min) (cmH2O) (cmH2O/ms)
WT: I/R 12 378±9 2.3±0.1 150±6 8.9±0.5 −6.0±0.4 286±10 1.8±0.1 68±2 5.1±0.3 −4.1±0.3
qKO: I/R 8 363±19 2.4±0.1 141±6 8.1±0.3 −5.2±0.2 315±22 1.8±0.1 97±5 5.7±0.4 −3.8±0.2
WT: PC & I/R 4 376±13 2.3±0.1 144±16 9.5±0.8 −7.1±0.6 350±9 1.8±0.1 108±12 7.4±0.9 −5.6±0.6
qKO: PC & I/R 8 352±8 2.4±0.1 127±7 8.5±0.5 −6.6±0.3 302±19 1.8±0.1 97±8 6.5±0.4 −5.4±0.2

The values are the mean ± SE. n, number of hearts; HR, heart rate (beats per min, bpm); FR, flow rate (ml/min); LVDP, left ventricular developed pressure (cmH2O); ±dp/dt, rates of pressure rise and fall (cmH2O/ms), respectively. The groups are: WT: I/R, Wild type subjected to ischemia-reperfusion without preconditioning; qKO: I/R, Quadruple knockout type subjected to ischemia-reperfusion without preconditioning; WT: PC & I/R, Wild type subjected to preconditioning and then ischemia-reperfusion; qKO: PC & I/R, Quadruple knockout type subjected to preconditioning and then ischemia-reperfusion.