Table 3.
Cytotoxic activity of the investigated compounds. Cells were treated for 72 h and the viability was measured using MTT assay. IC50s were calculated using GraphPad Prism software. Additionally, the viability of the cells treated with 100 µM of the compounds is presented and the selectivity index (SI) was calculated as [viability of PNT-2 cells]/[viability of 22Rv1 cells]. Docetaxel was used as a positive control.
| Compound | IC50 | Viability at 100 µM, % of Control | SI | ||
|---|---|---|---|---|---|
| 22Rv1 Cells | PNT-2 Cells | 22Rv1 Cells | PNT-2 Cells | ||
| 1 | >100 µM | >100 µM | 65.5% ± 1.3% | 97.2% ± 3.5% | 1.48 |
| 1a | >100 µM | >100 µM | 62.2% ± 4.7% | 80.4% ± 0.5% | 1.29 |
| 2 | >100 µM | >100 µM | 61.9% ± 3.6% | 82.9% ± 1.5% | 1.34 |
| 7 | >100 µM | >100 µM | 63.8% ± 2.5% | 80.7% ± 8.1% | 1.26 |
| 8 | 71.74 ± 8.9 µM | >100 µM | 38.7% ± 3.4% | 88.1% ± 3.1% | 2.28 |
| 9 | >100 µM | >100 µM | 54.9% ± 6.9% | 55.5% ± 4.1% | 1.01 |
| Docetaxel | 2.78 ± 1.07 nM | 84.74 ± 20.58 nM | - | - | - |