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. 2019 Oct 14;6(23):1901152. doi: 10.1002/advs.201901152

Figure 2.

Figure 2

Excitatory and inhibitory responses and excitability of p14‐17 CA1‐pyramidal neurons to IGFBP2. A,B) Exemplar mEPSCs/mIPSCs in pyramidal neurons at –70 mV and the cumulative distributions of their frequency and amplitude (DNQX, AP5, and TTX added in incubation. n = 11 EPSCs, 12 IPSCs, 4‐6 washouts. C–G) Exemplar spikes, cumulative probability, plots of interspike interval, spike latency, and pyramidal neuron excitability (n = 8). H–J) Voltage threshold (n = 19), threshold current (n = 8), and normalized slope of initiation for spikes (n = 8). K) CA1‐FSI excitability (n = 5). Two‐sample Kolmogorov‐Smirnov test in panels A, B, and D; otherwise, paired two‐tailed t‐tests. * P < 0.05, ** P < 0.01, ***P < 0.001; data are mean ± SEM.