Table 2.
Multivariate analysis of risk factors for the development of new acute kidney injury
| Variables | OR | 95% CI for OR | p value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Age | 1.00 | 1.00 | 1.01 | 0.24 |
| BMI | 1.06 | 1.04 | 1.07 | <0.001 |
| SOFA score on admission to the ICU | 1.04 | 1.00 | 1.08 | 0.05 |
| Lowest MAP | 1.00 | 0.99 | 1.01 | 0.84 |
| Sepsis | 1.11 | 0.80 | 1.53 | 0.53 |
| Chronic kidney disease | 1.81 | 1.34 | 2.45 | <0.001 |
| Atherosclerotic cardiovascular disease | 1.13 | 0.90 | 1.40 | 0.29 |
| Congestive heart failure | 1.12 | 0.81 | 1.56 | 0.50 |
| Diabetes mellitus | 1.06 | 0.85 | 1.33 | 0.60 |
| Cancer | 0.84 | 0.69 | 1.03 | 0.10 |
| Mechanical ventilation | 0.94 | 0.77 | 1.17 | 0.60 |
| Norepinephrine use | 1.20 | 0.94 | 1.54 | 0.15 |
| NSAID use | 0.48 | 0.22 | 1.05 | 0.07 |
| Cumulative fluid balance on the day of AKI or day 3 in the ICU | 1.11 | 1.08 | 1.14 | <0.001 |
Model diagnostics:
There was no evidence of lack of fit (Hosmer Lemeshow p = 0.209) that the model was incorrectly specified (link test p = 0.300) or of multicollinearity among the included covariates (all variance inflation factors (VIF) < 1.5). There was no evidence of a non-linear relationship between cumulative fluid balance and AKI
BMI body mass index, CI confidence interval, MAP mean arterial pressure, NSAID non-steroidal anti-inflammatory drug, SOFA Sequential Organ Failure Assessment, OR odd ratio