Table 3.
Multivariate analysis for risk of non-recovery after acute kidney injury
| Variables | MVR (variables pre-AKI)1 | MVR (variables post-onset of AKI)2 | ||||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI for OR | p value | OR | 95% CI for OR | p value | |||
| Lower | Upper | Lower | Upper | |||||
| AKI stage | 1 | < 0.001 | ||||||
| AKI stage 2 | 0.63 | 0.31 | 1.28 | 0.21 | ||||
| AKI stage 3 | 2.24 | 1.16 | 4.31 | 0.02 | ||||
| SOFA score on admission to the ICU | 1.05 | 0.96 | 1.15 | 0.26 | ||||
| SOFA score on the day of AKI/day 3 | – | – | – | – | 1.10 | 0.99 | 1.22 | 0.09 |
| Lowest MAP on the day of AKI | – | – | – | – | 0.99 | 0.96 | 1.02 | 0.36 |
| Chronic kidney disease | 2.01 | 1.12 | 3.58 | 0.02 | 2.82 | 1.37 | 5.78 | 0.01 |
| Reason for admission: respiratory | 1.52 | 0.94 | 2.45 | 0.09 | ||||
| Mechanical ventilation | 2.29 | 1.24 | 4.26 | 0.01 | 4.34 | 2.05 | 9.15 | < 0.001 |
| Norepinephrine use | 1.21 | 0.64 | 2.30 | 0.56 | 0.56 | 0.25 | 1.26 | 0.16 |
| Vancomycin use | 1.10 | 0.48 | 2.48 | 0.83 | 1.40 | 0.65 | 3.01 | 0.39 |
| Diuretic use | 1.89 | 1.20 | 2.97 | 0.01 | ||||
| Aminoglycoside use | 1.13 | 0.69 | 1.83 | 0.63 | ||||
Model diagnostics:
There was no evidence of lack of fit (Hosmer Lemeshow p = 0.217 and 0.248) that the model was incorrectly specified (link test p = 0.082 and 0.345) or of multicollinearity among the included covariates (all variance inflation factors < 3) for model MVR 1 or MVR 2
AKI acute kidney injury, CI confidence interval, MAP mean arterial pressure, ICU intensive care unit, MVR multivariate analysis, NSAID non-steroidal anti-inflammatory drug, SOFA Sequential Organ Failure Assessment, OR odd ratio
1Also adjusted for the non-linear association between fluid balance and non-recovery (p < 0.001)
2Also adjusted for the non-linear association between net fluid balance and non-recovery (p = 0.016)