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. 2019 Dec 3;19:1180. doi: 10.1186/s12885-019-6333-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CAF-derived IL-6 decreased HIC1 expression in SK-BR-3 cells. HIC1 was decreased in SK-BR-3 cells cocultured with CAF40 and CAF74 compared to cells cocultured with NAF1. b-c HIC1 was decreased in SK-BR-3 by rhIL-6 in a time- and dose-dependent manner. d The decreased HIC1 induced by rhIL-6 was completely restored by STAT3 inhibition