Fig. 1.
Efficacy of SAAP-148 formulated in HM gels. a In vitro killing of 105 CFU/mL MRSA by 7.6 nmol SAAP-148 in 3:1 or 3:10 HM gel or the empty HM gel as negative control. The mixtures were either vortexed or not. The vortex mixing period is indicated on the x-axis. The mean ± SD of six experiments performed in duplicate is shown. # indicates significant difference compared to the LR at 30 s (##p < 0.01) and * indicates significant difference (*p < 0.05; **p < 0.01) compared to SAAP-148 in 3:10 HM. b The ex vivo efficacy of SAAP-148 in 3:1 or 3:10 HM gels. Excision wound models were inoculated with approximately 105 CFU for 4 h and exposed to 50 µL of 3:1 or 3:10 HM gels containing 38 nmol, 76 nmol, 152 nmol SAAP-148 or the empty HM gel (negative control) for 1 h. The mean of six independent experiments performed in triplicate is shown. Results are expressed as the LR