Fig. 8.

Efficacy of SAAP-148 in a rat model. The bacterial load of excision wounds from rats was determined using swabs (A/C) and punch biopsies (b, d) of the wounds. After an overnight inoculation with MRSA, the wounds were treated for 4 h (a, b) or 24 h (c, d) with 100 µL of 3:10 HM gel containing 306 or 612 nmol SAAP-148 or PBS containing 153 or 306 nmol SAAP-148 or the empty HM gel (negative control) or 2% (wt/wt) Bactroban (positive control). Results are expressed as the LR. Data represent the mean of at least five samples. * indicates significant difference (*p < 0.05; **p < 0.01)