Table 6.
List of 20 significant ‘GeneMANIA functions’ that were obtained using miRNA-targeted genes in Pancreatic Cancer
| Sl.no | Function | FDR | Genes in network |
|---|---|---|---|
| 1 | protein kinase binding | 4.84E-04 | 18 |
| 2 | extracellular matrix organization | 2.60E-03 | 17 |
| 3 | angiogenesis | 3.08E-03 | 15 |
| 4 | cell cycle G2/M phase transition | 3.08E-03 | 12 |
| 5 | microtubule cytoskeleton organization | 5.63E-03 | 14 |
| 6 | nuclear division | 6.74E-03 | 15 |
| 7 | response to oxygen levels | 8.77E-03 | 10 |
| 8 | platelet-derived growth factor binding | 8.79E-03 | 4 |
| 9 | cell cycle checkpoint | 1.11E-02 | 13 |
| 10 | intrinsic apoptotic signaling pathway | 1.13E-02 | 12 |
| 11 | response to oxidative stress | 1.31E-02 | 11 |
| 12 | regulation of angiogenesis | 1.40E-02 | 10 |
| 13 | transmembrane receptor protein serine/threonine kinase signaling pathway | 1.40E-02 | 13 |
| 14 | integrin binding | 1.42E-02 | 7 |
| 15 | regulation of mitosis | 3.14E-02 | 8 |
| 16 | epithelial to mesenchymal transition | 3.14E-02 | 7 |
| 17 | regulation of release of cytochrome c from mitochondria | 3.32E-02 | 5 |
| 18 | cell chemotaxis | 4.25E-02 | 10 |
| 19 | endothelial cell proliferation | 4.30E-02 | 7 |
| 20 | Rho protein signal transduction | 4.80E-02 | 6 |