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. 2019 Dec 3;10:368. doi: 10.1186/s13287-019-1485-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — iGMSCs obtained impaired stemness compared with GMSCs. a Micro-CT showed significant alveolar bone resorption in ligature-induced periodontitis in mice. b iGMSCs exhibited reduced single colony-forming ability. c, d Flow cytometric analysis of the expression of Sca1, CD105, CD90, CD73, CD44, CD45, and CD34 in iGMSCs and GMSCs. e Continued culture assay showed that iGMSCs had less elevated population doubling than GMSCs. f BrdU⁺ labeling assay showed decreased proliferation rate in iGMSCs compared with GMSCs. n = 5 in each group. *P < 0.05. **P < 0.01. ***P < 0.005. Error bars: mean ± SD