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. 2019 Dec 3;24:65. doi: 10.1186/s11658-019-0194-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — E₂ increased lipid secretion and the expression of HMGCR and LDLR mRNA in HepG2 cells. a The concentration of TC, TG, LDL-C and HDL-C in HepG2 cells after 24 h treatment with E₂ (10^− 7 mol/l). b and c The HMGCR (b) and LDLR (c) mRNA expression in HepG2 cells after 24 h treatment with E₂ (10^− 7 mol/l). The experiments were repeated three times and data are presented as means ± SEM. *p < 0.05 and **p < 0.01 compared with the corresponding control group. E₂: estradiol; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; LDLR: low-density lipoprotein receptor; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase