Fig. 1.

MORC2 attenuates histone and DNA interaction. a Knockout of MORC2 in HeLa and MCF-7 cells were carried out by the CRISPR/Cas9 system and validated by immunoblotting analysis with the indicated antibodies. b Nuclei were isolated from WT and MOCR2 KO HeLa or MCF-7 cells and subjected to salt solubilization assays. The core histones in salt soluble fractions were detected by immunoblotting using the indicated antibodies. NPM and hnRNPM are shown as loading controls