Table 1.
Top 15 significantly enriched pathways derived from the DEmRNAs
| ID | Description | P value | P adjust | q value | Gene ID | Count |
|---|---|---|---|---|---|---|
| hsa05322 | Systemic lupus erythematosus | 5.1E−20 | 1.47E−17 | 1.23E−17 |
ELANE/C7/HIST3H2A/CTSG/HIST1H2AD/HIST1H3D/HIST1H2BD/ HIST2H2BF/HIST1H3G/HIST1H2AE/HIST1H2BJ/HIST3H2BB/ HIST1H2BO/HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2AG/ HIST1H2BE/HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/ HIST1H3B/HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/ HIST1H2AH/HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/ HIST1H2BN/HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/ HIST1H4B/HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/ HIST1H2AB/HIST1H3A/HIST1H4A/HIST1H4H/FCGR3A/ HIST1H2BB/HIST1H2AJ/H2BFM/HIST1H4F/HIST1H4L |
52 |
| hsa05034 | Alcoholism | 3.48E−18 | 5.02E−16 | 4.2E−16 |
FOSB/GNAO1/GNG7/ADCY5/MAOB/HIST3H2A/HIST1H2AD/ HIST1H3D/HIST1H2BD/HIST2H2BF/HIST1H3G/HIST1H2AE/ HIST1H2BJ/GRIN2D/HIST3H2BB/HIST1H2BO/HIST1H4I/ HIST1H2BG/HIST1H2BH/GRIN3B/HIST1H2AG/HIST1H2BE/ HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/HIST1H3B/ HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/HIST1H2AH/ HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/HIST1H2BN/ HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/HIST1H4B/ HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/HIST1H2AB/ GRIN1/HIST1H3A/HIST1H4A/HIST1H4H/HIST1H2BB/ HIST1H2AJ/GNG4/GNG13/H2BFM/HIST1H4F/TH/HIST1H4L |
59 |
| hsa04080 | Neuroactive ligand–receptor interaction | 9.5E−10 | 9.12E−08 | 7.63E−08 |
GLP2R/TACR2/P2RX1/P2RY14/VIPR2/TACR3/PTGFR/CHRM2/ ADRB3/AGTR1/CHRM3/LEPR/ADCYAP1R1/PTH1R/BDKRB1/ BDKRB2/ADRA1D/GHR/HTR1B/CTSG/TACR1/GRIN2D/ CHRNA1/GRIN3B/PTGER3/GRIK3/HTR2A/GABRG1/SSTR1/ S1PR5/GALR1/LHB/PRSS2/PRSS1/GRIN1/GRM4/MTNR1B/ GABRA4/KISS1R/OXTR/CHRNG/CHRNB2/PRLHR/CHRND/ CHRNA9/GRM3/GALR2/CHRNA6/GPR83/GLP1R/GLRA3/ SCTR/F2/DRD5/GABRR3/HTR2C/RXFP3/GHRHR/GABBR2/PRL |
60 |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.34E−09 | 9.68E−08 | 8.1E−08 |
TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/ITGA7/ SGCA/RYR2/SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/ ITGA1/TNNT2/IL6/CACNB4/PRKAA2/CACNA2D1/ITGB3/ MYL3/TNNI3/CACNG4/CACNG1 |
28 |
| hsa05414 | Dilated cardiomyopathy (DCM) | 2.31E−09 | 1.33E−07 | 1.11E−07 |
TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/PLN/ ITGA7/SGCA/RYR2/SLC8A1/LAMA2/DES/ADCY5/SGCD/ SGCG/ITGA5/ITGA9/ITGA1/TNNT2/CACNB4/CACNA2D1/ ITGB3/MYL3/ADCY2/TNNI3/CACNG4/CACNG1 |
29 |
| hsa04020 | Calcium signaling pathway | 6.17E−08 | 2.96E−06 | 2.48E−06 |
PLCD4/MYLK/TACR2/ITPKB/RYR3/CACNA1H/PDE1C/P2RX1/ ITPR1/GNAL/CACNA1C/PLN/PDE1A/CAMK2A/TACR3/RYR2/ PTGFR/SLC8A1/PLCB4/CHRM2/ADRB3/AGTR1/CHRM3/ BDKRB1/BDKRB2/ADRA1D/PRKCB/TACR1/SLC8A3/GRIN2D/ ADCY2/PTGER3/SLC8A2/HTR2A/GRIN1/OXTR/CAMK2B/ CACNA1E/MYLK4/DRD5/CACNA1B/HTR2C |
42 |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 5.72E−07 | 2.35E−05 | 1.97E−05 |
DMD/ITGA8/ACTN2/CACNB2/CACNA1C/ITGA7/SGCA/RYR2/ SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/ITGA1/ CACNB4/CACNA2D1/ITGB3/CTNNA3/CACNG4/CACNG1 |
22 |
| hsa04713 | Circadian entrainment | 2.72E−06 | 8.74E−05 | 7.32E−05 |
RYR3/CACNA1H/PER2/ITPR1/FOS/CACNA1C/GNAO1/CAMK2A/ GNG7/PRKG1/RYR2/PLCB4/ADCY5/PER1/ADCYAP1R1/PRKCB/ KCNJ3/GRIN2D/ADCY2/GRIN1/MTNR1B/CAMK2B/KCNJ6/ GNG4/GNG13 |
25 |
| hsa04974 | Protein digestion and absorption | 2.73E−06 | 8.74E−05 | 7.32E−05 |
ATP1A2/SLC8A1/COL14A1/ATP1B2/XPNPEP2/COL10A1/CPA3/ COL21A1/SLC8A3/COL11A1/ELN/COL4A4/COL4A6/SLC8A2/ COL7A1/COL2A1/COL6A5/PRSS2/SLC15A1/PRSS1/MEP1A/ ATP1A3/CPB2/SLC6A19 |
24 |
| hsa04911 | Insulin secretion | 3.35E−06 | 9.66E−05 | 8.09E−05 |
KCNMA1/KCNMB1/ATP1A2/CACNA1C/CAMK2A/RYR2/PLCB4/ ADCY5/ATP1B2/CHRM3/ADCYAP1R1/ADCYAP1/KCNN2/ PRKCB/ADCY2/ABCC8/PDX1/CAMK2B/ATP1A3/GLP1R/INS/ SLC2A2/GIP |
23 |
| hsa05203 | Viral carcinogenesis | 6.19E−06 | 0.000162 | 0.000136 |
EGR3/GSN/JUN/CDK1/EGR2/CDC20/CCNE1/HIST1H2BD/ HIST2H2BF/HIST1H2BJ/CCNE2/HIST3H2BB/HIST1H2BO/ HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2BE/HIST1H2BF/ HIST1H2BC/HIST1H2BK/HIST1H4E/GTF2A1L/HIST2H4A/ CCR3/CDKN2A/HIST1H2BM/HIST1H4D/HIST1H2BN/ HIST1H2BI/HIST1H4C/ATP6V0D2/HIST1H4B/HIST1H2BL/ HIST1H4A/HIST1H4H/HIST1H2BB/H2BFM/HIST1H4F/ HPN/HIST1H4L |
40 |
| hsa04512 | ECM–receptor interaction | 2.24E−05 | 0.000538 | 0.00045 |
TNXB/ITGA8/ITGA7/THBS1/LAMA2/ITGA5/ITGA9/ITGA1/ LAMC3/ITGB3/HMMR/COL4A4/COL4A6/SPP1/IBSP/ COL2A1/COL6A5/LAMC2/GP6/COMP/TNN |
21 |
| hsa04921 | Oxytocin signaling pathway | 0.000104 | 0.00231 | 0.001933 |
PPP1R12B/MYLK/RYR3/MYL9/ITPR1/RCAN1/FOS/ CACNB2/CACNA1C/GNAO1/CAMK2A/RGS2/RYR2/ PLCB4/JUN/ADCY5/CACNB4/PRKAA2/CACNA2D1/ PRKCB/PTGS2/KCNJ3/ADCY2/OXTR/CACNG4/ CAMK2B/KCNJ6/MYLK4/KCNJ4/CACNG1 |
30 |
| hsa04024 | cAMP signaling pathway | 0.000131 | 0.002696 | 0.002257 |
MYL9/FOS/ATP1A2/PDE4D/CACNA1C/PLN/ CAMK2A/FXYD1/VIPR2/CNGA3/RYR2/JUN/CHRM2/ ADCY5/ATP1B2/ADCYAP1R1/RAC3/HTR1B/HHIP/ GRIN2D/ADCY2/GRIN3B/TNNI3/PTGER3/CNGB1/ SSTR1/CNGB3/AMH/GRIN1/OXTR/CAMK2B/ SUCNR1/ATP1A3/GLP1R/DRD5/GABBR2 |
36 |
| hsa04261 | Adrenergic signaling in cardiomyocytes | 0.000229 | 0.004393 | 0.003677 |
TPM1/CACNB2/ACTC1/ATP1A2/CACNA1C/TPM2/ PLN/CAMK2A/RYR2/SLC8A1/PLCB4/ADCY5/ ATP1B2/TNNT2/AGTR1/SCN7A/CACNB4/SCN4B/ PPP1R1A/ADRA1D/CACNA2D1/MYL3/ADCY2/ TNNI3/CACNG4/CAMK2B/ATP1A3/CACNG1 |
28 |