Table 3.
Comparison of Model performance among ischemic stroke patients in the validation cohort (N = 2331, discharged between April 1, 2012 and March 31, 2013)
| Outcome | Model | H-L X2† (df) |
P value | C-statistic (95% CI) |
P value* | cNRI¥ (95% CI) |
P value* |
|---|---|---|---|---|---|---|---|
| In-hospital mortality | Age/sex adjusted CCI |
9.56 (8) |
0.297 |
0.722 (0.688, 0.756) |
|||
| Age/sex adjusted ISCCI | 8.35 (8) | 0.400 |
0.729 (0.695, 0.762) |
0.343 |
−0.121 (−0.260,0.017) |
0.08 | |
| Age/sex adjusted ISCCI-AF |
22.01 (8) |
0.005 |
0.720 (0.686, 0.753) |
– | – | ||
| 30-day mortality | Age/sex adjusted CCI |
10.42 (8) |
0.236 |
0.732 (0.700, 0.763) |
|||
| Age/sex adjusted ISCCI |
11.65 (8) |
0.234 |
0.746 (0.715, 0.777) |
0.009 |
0.041 (−0.087,0.170) |
0.53 | |
| Age/sex adjusted ISCCI-AF |
12.95 (8) |
0.113 |
0.737 (0.706, 0.768) |
– | |||
| One-year mortality | Age/sex adjusted CCI |
7.38 (8) |
0.391 |
0.760 (0.738, 0.783) |
|||
| Age/sex adjusted ISCCI |
7.33 (8) |
0.501 |
0.764 (0.741, 0.786) |
0.398 |
−0.086 (−0.181,0.010) |
0.08 | |
| Age/sex adjusted ISCCI-AF |
15.63 (8) |
0.075 |
0.755 (0.732, 0.777) |
– |
H-L Hosmer-Lemeshow, cNRI continuous net reclassification improvement, CCI Charlson comorbidity index, ISCCI Ischemic stroke Charlson comorbidity index, ISCCI-AF Ischemic stroke Charlson comorbidity index with atrial fibrillation included in the development model
†chi-square
*p-value for Area Under the Curve (AUC) and cNRI difference between age&sex adjusted CCI and age&sex adjusted ISCCI
¥difference between age/sex adjusted CCI and age/sex adjusted ISCCI