Table 3.

Summary of the causal effects of T2D and T2D-related glycemic/anthropometric traits on ALS with various MR methods

Exposures (unit)	Random-effects IVW	Weighted median	MR-Egger
			Odds ratio	Intercept (p value)
T2D	0.93 (0.87–1.00)	0.94 (0.86–1.03)	0.90 (0.72–1.14)	0.002 (0.786)
BMI (4.8 kg/m2)	1.00 (0.87–1.16)	0.93 (0.77–1.13)	0.80 (0.56–1.15)	0.007 (0.170)
Fasting glucose (mmol/L)	1.09 (0.90–1.31)	1.08 (0.98–1.43)	1.10 (0.97–1.57)	0.001 (0.852)
Fasting insulin (pmol/L)	0.78 (0.49–1.24)	0.66 (0.33–1.31)	1.91 (0.06–61.7)	−0.015 (0.615)
HbA1c (%)	0.97 (0.67–1.39)	0.85 (0.55–1.32)	0.95 (0.47–1.91)	0.001 (0.875)