Fig. 1.

a Schematic to show sequence of immunization with OVA in alum (given ip) and anti-idiotype Ig and immune Ig (both given im at separate sites) in naïve mice. All mice received egg white solution (EWS) in their drinking supply from the time shown (day 7). Animals were sacrificed for measure of OVA-specific IgG and IgE and OVA-induced cytokines in 72 h cultures of splenocytes. b Similar schematic to show sequence of immunization with OVA in alum (given ip) and anti-idiotype Ig and immune Ig (both given im at separate sites) in mice immunized with OVA before treatment with Igs. All mice received egg white solution (EWS) in their drinking supply throughout study from the time shown (day 7). Tail bleeds were used at 52 days to assess induction of OVA-IgG and IgE, and animals were sacrificed for measure of OVA-specific IgG and IgE and OVA-induced cytokines in 72 h cultures of splenocytes 10 days after a final OVA boost (d 96)