Fig. 6.

Schematic to show sequence of delivery of iv anti-CD4, anti-CD8 or combined anti-CD4⁺ anti-CD8 in mice preimmunized with OVA in alum (given ip) and receiving anti-idiotype Ig and immune Ig (both given im at separate sites). All mice received egg white solution (EWS) in their drinking supply from the time shown (day 7) throughout the course of study. Animals were sacrificed for measure of OVA-specific IgG and IgE and OVA-induced cytokines in 72 h cultures of splenocytes. Tail bleeds were used at 52 days to assess induction of OVA-IgG and IgE, and animals were sacrificed for measure of OVA-specific IgG and IgE and OVA-induced cytokines in 72 h cultures of splenocytes 10 days after a final OVA boost (day 96)