Table 4.

Distribution of the single nucleotide polymorphisms (SNPs) at the open reading frame (ORF) of the prion protein gene (PRNP) in various species

Species	Polymorphisms	Total, n	Ref.
Human	G54S, P68P, G114 V, G127 V, M129 V, G142S, R148H, N171S, D178N, V180I, T183A, T188K, E200K, V203I, R208H, V210I, E211Q, E219K, M232R, P238S	20	[6, 31, 32]
Sheep	S98R, Q101R, M112 T, A116P, A116E, G127S, A136V, A136T, M137 T, S138R, L141F, I142K, H143R, G145 V, N146S, D147E, Y152F, R154H, P168L, Q171R, Q171H, Q171K, Y172D S173 N, Q175R, N176K, V179E, N184H, Q189L, R231R, L237 L	31	[33–36]
Goats	W18R, V21A, L23P, G37 V, P42P, G49S, Q101R, Q101Q, W102G, K107K, T110P, V125 V, G127S, L133Q, M137I, S138S, I142M, I142T, I42I, H143R, N146D, N146S, R151H, R154H, P168Q, V179 V, D181D, T194P, F201F, T202 T, K207K, R211Q, R211G, I218L, T219 L, Q220H, Q222K, Q222Q, G232 W, G232G, S240P	41	[37, 38]
Cattle	K3T, S8S, V21E, S46I, N50S, P54S, G58G, G66G, G67S, W68R, G73A, Q78Q, G83G, K117K, M145 V, S146 N, S154S, S154 N, Y156C, Y174C, N184D, N185 N, N192 N, V200F, V200A, T204A, K205E, F209S, T210 T, T212A, K215R, M216 T, Q223H, I244V, L245F, P249P, I252F, L253P	38	[22–25]
Horse	N175K	1	[5]
Chickens	NDa	0	[30], This study

^aND Not Detected