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. 2019 Oct;189(10):1986–2001. doi: 10.1016/j.ajpath.2019.07.003

Figure 1.

Figure 1

Mice were treated with 300 mg/kg acetaminophen (APAP), followed by treatment with tranexamic acid, as detailed in Materials and Methods. A: Alanine aminotransferase (ALT) activity was measured at the indicated times. B–D: mRNA levels of tumor necrosis factor (TNF)-α (B), Cxcl1 (C), and Cxcl2 (D) were measured 8 hours after APAP treatment. E: Chemokine (C-C motif) ligand (Ccl2) protein was measured in the serum. Data are expressed as means ± SEM (A–E). n = 5 mice per group (A–E). *P < 0.05 versus vehicle.