Figure 10.

Mice were treated with 300 mg/kg acetaminophen (APAP), followed by treatment with tranexamic acid (TA) for 24 and 48 hours, as detailed in Materials and Methods. A and B: Ly6G⁺ neutrophils were detected in liver sections from mice treated 24 hours earlier with either APAP and water (A) or APAP and tranexamic acid (B). The necrotic lesions are demarcated by dashed lines. Insets show images are higher magnification, with neutrophils indicated by arrows. C: The number of neutrophils was quantified. Data are expressed as means ± SEM (C). n = 5 mice per group (C). Original magnification: ×100 (A and B, main images); ×400 (A and B, insets).