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. 2019 Oct;189(10):1986–2001. doi: 10.1016/j.ajpath.2019.07.003

Figure 2.

Figure 2

A–C and E–G: Kupffer cells (A–C) and bone marrow–derived macrophages (BMMs; E–G) were treated with 100 nmol/L plasmin. mRNA levels of the indicated cytokines were measured 6 hours later. D: Photomicrographs of BMMs treated with vehicle or plasmin for 18 hours. H and I: BMMs were treated with 100 nmol/L plasmin in the presence or absence of D-Val-Phe-Lys chloromethyl ketone (D-Val; H) or tranexamic acid (TA; I). Tumor necrosis factor (TNF)-α mRNA levels were quantified. J–L: BMMs were treated with vehicle or the indicated concentration of plasminogen. mRNA levels of the indicated cytokines were measured 6 hours later. Data are expressed as means ± SEM (A–C and E–L). n = 3. *P < 0.05 versus control; †P < 0.05 versus vehicle. Original magnification, ×400 (D). Ccl, chemokine (C-C motif) ligand.