Figure 5.

Mice were treated with 300 mg/kg acetaminophen, followed by treatment with tranexamic acid, as detailed in Materials and Methods. A–D: Photomicrographs of sections of hematoxylin and eosin–stained liver sections. E: Area of necrosis was quantified in sections of liver. Data are expressed as means ± SEM (E). n = 5 mice per group (E). *P < 0.05 versus tranexamic acid. Original magnification, ×100 (A–D).