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Mice were treated with 300 mg/kg acetaminophen, followed by treatment with tranexamic acid, as detailed in Materials and Methods. C3b/iC3b/C3c was detected by immunofluorescence. A–D: Representative photomicrographs of sections of hematoxylin and eosin–stained liver sections. E: Area of C3b/iC3b/C3c immunostaining was quantified in sections of liver. Data are expressed as means ± SEM (E). n = 5 mice per group (E). *P < 0.05 versus tranexamic acid. Original magnification, ×200 (A–D).
