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. 2019 Oct;189(10):1986–2001. doi: 10.1016/j.ajpath.2019.07.003

Figure 8.

Figure 8

Mice were treated with 300 mg/kg acetaminophen, followed by treatment with tranexamic acid, as detailed in Materials and Methods. A and B: CD68 was detected by immunofluorescence. The necrotic lesions are demarcated by dashed lines. C: Area of CD68 fluorescence was quantified in sections of liver. D–G: F4/80 was detected by immunofluorescence. H: Area of F4/80 immunostaining was quantified in sections of liver. Data are expressed as means ± SEM (C and H). n = 5 mice per group (C and H). *P < 0.05 versus vehicle. Original magnification, ×200 (A, B, and D–G).