Fig. 1.

Summary of key model characteristics related to type of vaccine, vaccination strategy, target population, setting and outcomes. Additional details found in Supplemental Table S1, Fig. 2, Fig. 3. The prophylactic and therapeutic vaccine studies focus vaccination on HSV-2 negative and positive people, respectively. 1-sex models combine males and females; 2-sex models represent females and males separately, allowing for vaccination of one or both sexes. A sexually active target population refers to vaccination of people who are already having sex; a sexual debut target population refers to vaccination of people before they become sexually active.