Table 3.

Non replicating rotavirus vaccines.

Vaccine	Characteristics	Developer	Development progress
Inactivated rotavirus vaccine (IRV)	Heat inactivated human rotavirus (G1P[8])	CDC, USA	Preclinical: mice/monkeys
	– Grows to high titer		Immunogenic
			Protective in animal model
			– Clinical lot prepared
			– Process development
Expressed proteins (based on VP6 inner capsid)	Truncated VP6	Cincinnati Children's Hospital Med Cent, USA	Animal studies
	VP6 combined with norovirus VLP	University of Tampere School of Medicine, Finland	– Immunogenic
			– Protected in challenge
			– Low yields
Virus like particles	Virus-like particles	Baylor College of Medicine, USA	Animal studies
	VP2/6/7; VP2/4/6/7		– Immunogenic
			– Protective small animals (predom. Homotypic)
			– Low yields/process difficult
VP8 expressed proteins (NRRV)	Trivalent truncated VP8: P[4], P[6] and P[8]	PATH, National Institutes of Health, USA	Human Phase I/II studies ongoing:
			Phase 2a immunogenicity – P[8] monovalent vaccine
			Phase 2a/b safety & immunogenicity of trivalent vaccine