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. 2019 Nov 1;158:107728. doi: 10.1016/j.neuropharm.2019.107728

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Profile of expression level changes for each protein tested at different stages of epileptogenesis.

Ratio between average RISE and AMC immunoblot intensity values in both the hippocampus and the temporal lobe. For each set of samples (SE, LP, SRS) the mean value of the AMC immunoblots was set to 1 (dotted line) and the mean of the corresponding RISE data plotted to illustrate the profile of change at different stages of epileptogenesis in the hippocampus and the temporal lobe.

(A) Ratio of GluA1, GluA2 and GluA3 subunit levels. (B) Ratio of GluK2 and GluK5 subunit levels. (C) Ratio of GluN1, GluN2A and GluN2B subunit levels. (D) Ratio of mGluR1α, mGluR5 and CB1 receptor levels. (E) Ratio of GABA_A β3 subunit and gephyrin (inhibitory synapse marker) levels. (F) Ratio of synaptophysin and PSD95 (excitatory synapse markers) levels.