Fig. 5.

Correlation between changes in receptors and synaptic marker proteins in hippocampus and temporal lobe at different stages of epileptogenesis.

(A) Scatterplot showing no correlation between levels of the pre-synaptic protein synaptophysin and GluK2 (KARs have both pre- and postsynaptic localisation) in hippocampus (r = −0.921, p = 0.2547, n = 5).

(B) Scatterplot showing no correlation between levels of the post-synaptic protein of excitatory synapses PSD95 and significantly altered post-synaptic receptor subunits in hippocampus. GluA1 (r = −0.309, p = 0.8000, n = 5), GluA2 (r = −0.7034, p = 0.5033, n = 5), GluA3 (r = −0.5376, p = 0.6387, n = 5), GluK2 (r = 0.9502, p = 0.2017, n = 5), GluN2A (r = −0.751, p = 0.4591, n = 5), and mGluR1⍺ (r = 0.736, p = 0.4735, n = 5).

(C) Scatterplot showing no correlation between gephyrin, a post-synaptic scaffold at inhibitory synapses, and levels of GABA_Aβ3 in hippocampus (r = 0.9875, p = 0.1007, n = 5).

(D) Scatterplot showing no correlation between levels of pre-synaptic protein synaptophysin and the KAR subunit GluK5 in temporal lobe (r = 0.5097, p = 0.6595, n = 5).

(E) Scatterplot showing no correlation between levels of PSD95 and significantly altered post-synaptic receptor subunits in temporal lobe. GluA1 (r = 0.7936, p = 0.4164, n = 5), GluA2 (r = −0.1451, p = 0.9073, n = 5), GluA3 (r = 0.3037, p = 0.8036, n = 5), GluK5 (r = 0.09309, p = 0.9406, n = 5), GluN1 (r = 0.7315, p = 0.4777, n = 5), GluN2A (r = −0.7079, p = 0.4993, n = 5), GluN2B (r = 0.9824, p = 0.1198, n = 5), mGluR1⍺ (r = 0.9415, p = 0.2189, n = 5), and mGluR5 (r = 0.8046, p = 0.4047, n = 5).

(F) Scatterplot showing no correlation between levels of gephyrin and GABA_Aβ3 in temporal lobe (r = −0.8509, p = 0.3521, n = 5).