Figure 3.

Neutralization Potency of Different diFab and triFab Designs

(A and B) Predicted IC₅₀s for (A) diFab or (B) triFab constructs with linkers composed of d bp dsDNA and $s$ bases ssDNA segments. In both cases, optimal neutralization occurs when the linker matches the length between Fab binding sites $\left(d=\left(3\text{bp}/\text{nm}\right)l_{\text{linker}}=60\text{bp}\right)$ and has as little ssDNA as possible. The triFab can achieve significantly enhanced potency over the diFab because of its additional avidity.