Table 1.
Statistical analysis of severe hypoglycemia across diabetes duration categories and treatment arms
| <10 years | 10-15 years | 15-20 years | ≥20 years | |||||
|---|---|---|---|---|---|---|---|---|
| IGlar U100 (n=986) |
Degludec (n=906) |
IGlar U100 (n=938) |
Degludec (n=912) |
IGlar U100 (n=769) |
Degludec (n=805) |
IGlar U100 (n=1126) |
Degludec (n=1195) |
|
| Number and proportion of patients with SH, n (%) |
54 (5.5) | 29 (3.2) | 45 (4.8) | 46 (5.0) | 50 (6.5) | 35 (4.3) | 103 (9.1) | 77 (6.4) |
| Rate of SH | 4.5 | 2.5 | 5.7 | 4.5 | 4.9 | 3.6 | 9.7 | 5.0 |
| Relative risk of SH (degludec vs. IGlar) (95% CI) | 0.48 (0.29-0.81) | 0.76 (0.48-1.21) | 0.68 (0.40-1.14) | 0.52 (0.35-0.77) | ||||
Degludec: Insulin degludec; IGlar U100: Insulin glargine 100 units/mL; Rate: Events per 100 patient-years of observation; SH: Severe hypoglycemia; CI: Confidence interval