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. 2019 Jul 3;25(7):1082–1088. doi: 10.1038/s41591-019-0505-4

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© The Author(s), under exclusive licence to Springer Nature America, Inc. 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — PCA biplot of participants challenged with typhoid fever following challenge with TN (n = 19) or wild-type (n = 21) S. Typhi based on all clinical, microbiological and laboratory measures. The data points are colored by challenge agent allocation. The ellipses represent the 95% confidence levels for challenge agent. The biplot arrows represent the contributions of individual variables to a given principal component, scaled according to their relative contribution³⁶.

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