Table 2.

ORs and 95% CIs for AMD Incidence by 25(OH)D Concentrations Defined by Using Both Tertiles and Clinical Outpoints of 25(OH)D (N = 1225): the ARIC Study

Model	Tertiles of 25(OH)D, nM, Range			P Value for Trend*
	Tertile 1 (10.8–53.6)	Tertile 2 (53.7–69.3)	Tertile 3 (69.4–173.0)
No. outcome/total No.	47/408	48/409	44/408
Age-adjusted	1	0.92 (0.59–1.42)	0.83 (0.53–1.30)	0.96
Weighted†	1	1.11 (0.65–1.90)	0.89 (0.51–1.54)	0.88
Model 1‡	1	0.70 (0.45–1.10)	0.57 (0.36–0.90)	0.11
Weighted	1	0.88 (0.53–1.48)	0.66 (0.38–1.16)	0.32
Model 2§	1	0.79 (0.50–1.26)	0.61 (0.38–0.99)	0.37
Weighted	1	0.97 (0.57–1.64)	0.73 (0.41–1.31)	0.63
Model	Clinical Cutpoints Defined by 25(OH)D, nM			P Value for Trend*
	<50 Deficient/Inadequate	50 to <75 Adequate	≥75 Adequate
No. outcome/total No.	33/316	69/599	37/310
Age-adjusted	1	1.02 (0.65–1.60)	1.04 (0.62–1.72)	0.96
Weighted	1	1.52 (0.87–2.66)	1.33 (0.71–2.50)	0.88
Model 1‡	1	0.75 (0.47–1.19)	0.68 (0.40–1.15)	0.11
Weighted	1	1.20 (0.61–2.34)	0.99 (0.48–2.05)	0.32
Model 2§	1	0.87 (0.54–1.42)	0.79 (0.45–1.38)	0.37
Weighted	1	1.38 (0.69–2.77)	1.17 (0.56–2.47)	0.63

Bolded values represent statistically significant results at a P value of < 0.05 or smaller.

^*P for trend calculated by using season-adjusted serum 25(OH)D as a continuous variable.

^†Inverse probability weights applied; n = 2 individuals missing weights.

^‡Model 1: adjusted for age, race, and smoking status.

^§Model 2: adjusted for age, race, and smoking status and composite physical activity index averaging visits 1 and 3 data (n = 46 participants were missing this variable).