Table 3.
Overview of Secondary Syndromic Forms of Myopia: Ocular Syndromes Associated With Myopia
|
Title |
Gene and Inheritance Pattern |
| Achromatopsia | CNGB3 (AR) |
| Aland Island eye disease | GPR143 (XLR) |
| Anterior-segment dysgenesis | PITX3 (AD) |
| Bietti crystalline corneoretinal dystrophy | CYP4V2 (AD) |
| Blue cone monochromacy | OPN1LW; OPN1MW (XLR) |
| Brittle cornea syndrome | ZNF469; PRDM5 (AR) |
| Cataract | BFSP2; CRYBA2; EPHA2 (AD) |
| Colobomatous macrophthalmia with microcornea | CH |
| Cone dystrophy | KCNV2 (AD) |
| Cone rod dystrophy | C8orf37 (AR); RAB28 (AR); RPGR (XLR); CACNA1F (XLR) |
| Congenital microcoria | CH |
| Congenital stationary night blindness | NYX (XLR); CACNA1F (XLR); GRM6 (AR); SLC24A1 (AR); LRIT3 (AR); GNB3 (AR); GPR179 (AR) |
| Ectopia lentis et pupillae | ADAMTSL4 (AR) |
| High myopia with cataract and vitreoretinal degeneration | P3H2 (AR) |
| Keratoconus | VSX1 (AD) |
| Leber congenital amaurosis | TULP1 (AR) |
| Microcornea, myopic chorioretinal atrophy, and telecanthus | ADAMTS18 (AR) |
| Microspherophakia and/or megalocornea, with ectopia lentis and/or secondary glaucoma | LTBP2 (AR) |
| Ocular albinism | OCA2 (AR) |
| Primary open angle glaucoma | MYOC; OPTN (AD) |
| Retinal cone dystrophy | KCNV2 (AR) |
| Retinal dystrophy | C21orf2 (AR); TUB (AR) |
| Retinitis pigmentosa | RP1 (AD); RP2 (XLR); RPGR (XLR); TTC8 (AR) |
| Sveinsson chorioretinal atrophy | TEAD1 (AD) |
| Vitreoretinopathy | ZNF408 (AD) |
| Wagner vitreoretinopathy | VCAN (AD) |
| Weill-Marchesani syndrome | ADAMTS10 (AR); FBN1 (AD); LTBP2 (AR); ADAMTS17 (AR) |