Table 4.
Summary of Candidate Gene Studies Reporting Positive Association Results With Myopia
|
Gene |
Study |
Ethnicity |
Independent Confirmation |
Replication in GWAS |
| APLP2 | Tkatchenko et al. 2015131 | Caucasian | – | – |
| BMP2K | Liu et al. 2009155 | Chinese | – | – |
| CHRM1 | Lin et al. 2009156 | Han Chinese | X157 | – |
| CHRM1 | Guggenheim et al. 2010158 | Caucasian | X157 | – |
| CMET | Khor et al. 200955 | Chinese | – | – |
| COL1A1 | Inamori et al. 2007159 | Japanese | – | – |
| COL2A1 | Mutti et al. 200746 | Caucasian | – | – |
| COL2A1 | Metlapally et al. 200947 | Caucasian | – | – |
| CRYBA4 | Ho et al. 2012160 | Chinese | – | – |
| HGF | Han et al. 200654 | Han Chinese | – | – |
| HGF | Yanovitch et al. 2009161 | Caucasian | – | – |
| HGF | Veerappan et al. 201053 | Caucasian | – | – |
| IGF1 | Metlapally et al. 201057 | Caucasian | – | – |
| LUM | Wang et al. 200660 | Chinese | – | – |
| LUM | Chen et al. 2009162 | Han Chinese | – | – |
| LUM | Lin et al. 2010164 | Chinese | – | – |
| LUM | Guggenheim et al. 2010158 | Caucasian | – | – |
| MFN1 | Andrew et al. 2008164 | Caucasian | X165 | – |
| MMP1 | Wojciechowski et al. 2010130 | Amish | – | – |
| MMP1 | Wojciechowski et al. 201359 | Caucasian | – | – |
| MMP10 | Wojciechowski et al. 201359 | Caucasian | – | – |
| MMP2 | Wojciechowski et al. 2010130 | Amish | – | – |
| MMP2 | Wojciechowski et al. 201359 | Caucasian | – | – |
| MMP3 | Hall et al. 200958 | Caucasian | – | – |
| MMP9 | Hall et al. 200958 | Caucasian | – | – |
| MYOC | Tang et al. 200763 | Chinese | – | – |
| MYOC | Vatavuk et al. 2009167 | Caucasian | – | – |
| MYOC | Zayats et al. 2009168 | Caucasian | – | – |
| PAX6 | Tsai et al. 2008169 | Chinese | – | – |
| PAX6 | Ng et al. 2009170 | Han Chinese | – | – |
| PAX6 | Han et al. 2009171 | Han Chinese | – | – |
| PAX6 | Miyake et al. 2012172 | Japanese | – | – |
| PAX6 | Kanemaki et al. 2015173 | Japanese | – | – |
| PSARL | Andrew et al. 2008164 | Caucasian | – | – |
| SOX2T | Andrew et al. 2008164 | Caucasian | – | |
| TGFβ1 | Lin et al. 200650 | Chinese | – | X24 |
| TGFβ1 | Zha et al. 2009174 | Chinese | – | X24 |
| TGFβ1 | Khor et al. 201056 | Chinese | – | X24 |
| TGFβ1 | Rasool et al. 2013175 | Indian | – | X24 |
| TGFβ2 | Lin et al. 200951 | Han Chinese | – | – |
| TGIF | Lam et al. 200352 | Chinese | – | – |
| TGIF1 | Ahmed et al. 201452,176 | Indian | – | – |
| LAMA1 | Zhao et al. 2011177 | Chinese | – | – |
| UMODL1 | Nishizaki et al. 2009178 | Japanese | – | – |
X indicates independent conformation or replication in GWAS study with reference included.