Table 2.
Pathway | 2 mo | 1 yr | 2 yr | ||||
---|---|---|---|---|---|---|---|
No. of up | No. of down | No. of up | No. of down | No. of up | No. of down | ||
1 | Immune response | 14 | 34 | 8 | 9 | 12 | 11 |
2 | Transcription factor binding | 27 | 5 | 4 | 2 | 4 | 19 |
3 | Regulation of immune response | 11 | 27 | 9 | 4 | 12 | 9 |
4 | Regulation of response to external stimulus | 11 | 25 | 5 | 8 | 6 | 14 |
5 | Positive regulation of the immune system process | 16 | 28 | 10 | 4 | 12 | 11 |
6 | External side of the plasma membrane | 3 | 20 | 5 | 6 | 5 | 12 |
7 | Leukocyte migration | 5 | 16 | 1 | 5 | 3 | 6 |
8 | Vacuole | 15 | 14 | 9 | 6 | 15 | 8 |
9 | Regulation of cell activation | 9 | 24 | 7 | 6 | 10 | 9 |
10 | Lysosome | 14 | 14 | 8 | 6 | 13 | 6 |
11 | Cell migration | 18 | 26 | 7 | 5 | 9 | 16 |
12 | Response to wounding | 14 | 27 | 7 | 6 | 12 | 11 |
13 | Endosome | 15 | 24 | 5 | 9 | 12 | 15 |
14 | Carbohydrate binding | 4 | 23 | 2 | 1 | 3 | 7 |
15 | Leukocyte chemotaxis | 2 | 12 | 0 | 4 | 2 | 5 |
16 | Regulation of lymphocyte activation | 8 | 20 | 7 | 5 | 8 | 7 |
17 | Regulation of defense response | 9 | 22 | 2 | 5 | 4 | 10 |
18 | Regulation of locomotion | 14 | 21 | 7 | 6 | 7 | 14 |
19 | G-protein–coupled peptide receptor activity | 2 | 11 | 2 | 4 | 2 | 5 |
20 | Regulation of cell migration | 13 | 19 | 7 | 6 | 7 | 14 |
Top 20 pathways affected by Cx3cr1 genotype (KO versus WT) are shown, with the number of genes up-regulated or down-regulated at each time point. Pathways showed an overall increase (tan highlight) or decrease (blue highlight) in expression. Only genes with FDR < 0.05, fold change > 30%, and average expression > 4 TPM were included in the enrichment analysis.