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. 2019 Nov 27;2(6):e201900453. doi: 10.26508/lsa.201900453

Table 2.

Gene ontology pathways common to DEGs overtime.

Pathway 2 mo 1 yr 2 yr
No. of up No. of down No. of up No. of down No. of up No. of down
1 Immune response 14 34 8 9 12 11
2 Transcription factor binding 27 5 4 2 4 19
3 Regulation of immune response 11 27 9 4 12 9
4 Regulation of response to external stimulus 11 25 5 8 6 14
5 Positive regulation of the immune system process 16 28 10 4 12 11
6 External side of the plasma membrane 3 20 5 6 5 12
7 Leukocyte migration 5 16 1 5 3 6
8 Vacuole 15 14 9 6 15 8
9 Regulation of cell activation 9 24 7 6 10 9
10 Lysosome 14 14 8 6 13 6
11 Cell migration 18 26 7 5 9 16
12 Response to wounding 14 27 7 6 12 11
13 Endosome 15 24 5 9 12 15
14 Carbohydrate binding 4 23 2 1 3 7
15 Leukocyte chemotaxis 2 12 0 4 2 5
16 Regulation of lymphocyte activation 8 20 7 5 8 7
17 Regulation of defense response 9 22 2 5 4 10
18 Regulation of locomotion 14 21 7 6 7 14
19 G-protein–coupled peptide receptor activity 2 11 2 4 2 5
20 Regulation of cell migration 13 19 7 6 7 14

Top 20 pathways affected by Cx3cr1 genotype (KO versus WT) are shown, with the number of genes up-regulated or down-regulated at each time point. Pathways showed an overall increase (tan highlight) or decrease (blue highlight) in expression. Only genes with FDR < 0.05, fold change > 30%, and average expression > 4 TPM were included in the enrichment analysis.